Clinical Diffuse Lung Injury and Remodeling

Apoptosis in lung injury and remodeling.

The mode of cell death termed apoptosis, sometimes referred to as programmed cell death, is as critical a determinant of cell population size as is cell proliferation. Although best characterized in cells of the immune system, apoptosis is now known to be a key factor in the maintenance of normal cell turnover within structural cells in the parenchyma of virtually every organ. Recent interest i...

Diffuse Axonal Injury: Pathological and Clinical Aspects

Diffuse traumatic brain injury refers to widespread pattern of injury throughout the brain caused by traumatic disruption of nerve cells, with particular injury to the axons [1]. There are four principal types of traumatic brain injury: diffuse vascular injury, diffuse axonal injury, hypoxic-ischemic encephalopathy and diffuse brain swelling [2]. Clinically, DAI is characterized by generalized ...

Acute lung injury: clinical perspective

perspective Acute lung injury (ALI) and its more severe manifestation, acute respiratory distress syndrome (ARDS), are characterised by acute inflammation that affects the function of the gas exchange surface of the lung. The disorder affects all age groups, and has an incidence of approximately 200,000 cases per year in the United States and a mortality of around 35% (Rubenfeld et al., 2005). ...

Invited Review HIGHLIGHTED TOPIC Lung Growth and Repair Apoptosis in lung injury and remodeling

Li, Xiaopeng, Ruijie Shu, Gerasimos Filippatos, and Bruce D. Uhal. Apoptosis in lung injury and remodeling. J Appl Physiol 97: 1535–1542, 2004; 10.1152/ japplphysiol.00519.2004.—The mode of cell death termed apoptosis, sometimes referred to as programmed cell death, is as critical a determinant of cell population size as is cell proliferation. Although best characterized in cells of the immune ...

Mechanism of Tissue Remodeling in Sepsis-Induced Acute Lung Injury